HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2,6-Dichloro-5-fluoronicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2,6-Dichloro-5-fluoro-3-pyridinecarbonitrile | HCID 2733849 | — |
| Product | 2,6-Dichloro-5-fluoronicotinic acid | HCID 2733659 | — |
Reaction Steps
The known compound, 2,6-dichloro-5-fluoronicotinonitrile (60 g) was heated at 65°-75° C. for 1 hour in concentrated sulfuric acid. After addition of water, the mixture was further heated at 100°-110° C. for 2 hours to give 2,6-dichloro-5-fluoronicotinic acid (59.8 g), m.p. 155°-156° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04738968 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-4963239d284c4ef384a166c91abe293f |
| Source note | uspto-grants-1988_04 |