HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Benzyl-3-hydroxy-4-methanesulfonyloxymethylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | HCID 13959884 | HCID 13959884 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 1-Benzyl-3-hydroxy-4-methanesulfonyloxymethylpyrrolidine | HCID 20142458 | 53.5% |
Reaction Steps
The known compound, 1-benzyl-3-hydroxy-4-hydroxymethylpyrrolidine [see J. Org. Chem., 30, 740 (1965)] (110 g) was allowed to react in chloroform with methanesulfonyl chloride (60.9 g) in the presence of triethylamine to yield 1-benzyl-3-hydroxy-4-methanesulfonyloxymethylpyrrolidine (81 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04738968 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-e6960d2e7236433fad475648ad77d1c2 |
| Source note | uspto-grants-1988_04 |