HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 649146Generated: October 30, 2026
Chloroacetone → 7-Chloro-2-methylimidazo[2,1-a]isoquinoline
https://huagongshe.com/reaction/649146
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-Chloroisoquinolin-1-amine | HCID 13821825 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-Chloro-2-methylimidazo[2,1-a]isoquinoline | HCID 13821826 | 82.4% |
Reaction Steps
A mixture of 5-chloro-1-aminoisoquinoline (2.8 g), chloroacetone (5.4 g) and sodium bicarbonate (7.6 g) in anhydrous ethanol (35 ml) was heated at 60° C. for 16 hours and filtered by suction. The filtrate was evaporated in vacuo and the residual solid was washed with ethanol to give 7-chloro-2-methylimidazo[2,1-a]isoquinoline (2.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04738967 |
|---|
| Source dataset | uspto-grants-1988_04 |
|---|
| ORD ID | ord-fc89981060024128972547fa25e9b8cb |
|---|
| Source note | uspto-grants-1988_04 |
|---|
