2-Methylimidazole → HCID 70419791, compound

HRID 649150Notes

Reaction equation

HRID 649150 reaction equation
COS([O-])(=O)=O.[CH3:7][C:8]1[N:9]=[C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=[CH:12][N:11]2[C:20]=1[CH2:21][N+](C)(C)C.[CH3:26][C:27]1[NH:28][CH:29]=[CH:30][N:31]=1>C(O)C>[CH3:7][C:8]1[N:9]=[C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=[CH:12][N:11]2[C:20]=1[CH2:21][C:27]1([CH3:26])[N:31]=[CH:30][CH:29]=[N:28]1

Participants

4

Reactant 2

HCID 127492-MethylimidazoleHCID 13821866HCID 13821866, compound

Product 1

HCID 70419791HCID 70419791, compoundYield 37.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-methyl-3-trimethylammoniomethylimidazo[2,1-a]isoquinoline methylsulfate (3 g) and 2-methylimidazole (1.6 g) in ethanol (50 ml) was refluxed with stirring for 4 hours and evaporated in vacuo. To the residue was added water and the resulting precipitates were collected by filtration, dried and recrystallized from ethyl acetate to give 2-methyl-3-(2-methyl-1-imidazolylmethyl)imidazo[2,1-a]isoquinoline (0.85 g).

Workup

  1. temperaturewas refluxed
  2. customevaporated in vacuo
  3. additionTo the residue was added water
  4. customthe resulting precipitates
  5. filtrationwere collected by filtration
  6. customdried
  7. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-b479b33d861a4901bc97448c588d780c
Source dataset
uspto-grants-1988_04
Patent number
US04738967

Reaction notes

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