反应详情

Isoamyl nitrite (140 g) was added to a suspension of 7-chloro-2-methylimidazo[2,1-a]isoquinoline (17.1 g) in dioxane (170 ml) at 50° C. and the mixture was refluxed for 15 minutes. After being cooled, the resulting precipitate was collected by filtration, washed successively with dioxane and diethyl ether and dried in a desiccator to give 7-chloro-2-methyl-3-nitrosoimidazo[2,1-a]isoquinoline (7.7 g).

1. temperaturethe mixture was refluxed for 15 minutes
2. temperatureAfter being cooled
3. filtrationthe resulting precipitate was collected by filtration
4. washwashed successively with dioxane and diethyl ether
5. customdried in a desiccator