Thionyl Chloride → HCID 20142435, compound

HRID 649162Notes

Reaction equation

HRID 649162 reaction equation
[C:1]([C:4]1[N:8]2[CH:9]=[CH:10][C:11]3[C:16]([C:7]2=[N:6][C:5]=1[CH3:18])=[CH:15][CH:14]=[CH:13][C:12]=3[Cl:17])(O)=[O:2].S(Cl)([Cl:21])=O>>[ClH:17].[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:11]=1[CH:10]=[CH:9][N:8]1[C:4]([C:1]([Cl:21])=[O:2])=[C:5]([CH3:18])[N:6]=[C:7]12

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 13821856HCID 13821856, compound

Product 1

HCID 20142435HCID 20142435, compound

Procedure

A mixture of 3-carboxy-7-chloro-2-methylimidazo[2,1-a]isoquinoline (2.5 g) and thionyl chloride (20 ml) was refluxed for 1 hour and evaporated in vacuo. The residual solid was washed with benzene and dried in a desiccator to give 7-chloro-3-chloroformyl-2-methylimidazo[2,1-a]isoquinoline hydrochloride (2.75 g).

Workup

  1. temperaturewas refluxed for 1 hour
  2. customevaporated in vacuo
  3. washThe residual solid was washed with benzene
  4. customdried in a desiccator

Sources & evidence

ORD record
ord-6fc1c80213d74a22b2c41478c7e26089
Source dataset
uspto-grants-1988_04
Patent number
US04738967

Reaction notes

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