3-Methyl-8-acetoxy-5,6,7,8-tetrahydroquinoline → 3-Methyl-5,6,7,8-tetrahydroquinolin-8-ol

Participants

Reaction Conditions

Reaction Steps

4.11 Grams of 3-methyl-8-acetoxy-5,6,7,8-tetrahydroquinoline was dissolved in 15 ml of 30%-sodium hydroxide aqueous solution and 15 ml of methanol, the thus obtained mixture was stirred with heating at 65° C. for 3 hours. The solvent was removed by evaporation, and the residue thus obtained was purified by a silica gel column chromatography (eluent: n-hexane/ethyl acetate=5/1) to obtain 1.50 g of 3-methyl-8-hydroxy-5,6,7,8-tetrahydroquinoline.

Provenance & Evidence