反应详情

0.97 Gram of 7,8-dihydro-3-methylquinolin-5(6H)-one was dissolved in 20 ml of methanol, then to this solution was added 0.23 g of sodium borohydride under ice-cooled condition, the mixture was stirred at room temperature for 3 hours. To the reaction mixture was added water, then methanol was removed by evaporation, next extracted with chloroform, and the chloroform extract was dried with anhydrous magnesium sulfate. The solvent was removed by evaporation to obtain 0.98 g of 3-methyl-5-hydroxy-5,6,7,8-tetrahydroquinoline in the form of colorless oily substance.

1. temperaturecooled condition
2. custommethanol was removed by evaporation
3. extractionnext extracted with chloroform
4. extractionthe chloroform extract
5. dry with materialwas dried with anhydrous magnesium sulfate
6. customThe solvent was removed by evaporation