反应详情

To a solution of 3-methoxy-2-methyl-4-propoxypyridine (1.0 g) in carbon tetrachloride (70 ml), was added N-bromosuccinimide (1.0 g) and the mixture was irradiated with and infrared lamp (Toshiba, 100 V, 375 WR) for 2 hours at reflux. An insoluble substance was filtered off, and the filtrate was concentrated and purified by column chromatography on silica gel, to give 2-bromomethyl-3-methoxy-4-propoxypyridine (0.4 g) as a reddish brown oil.

1. customthe mixture was irradiated with and infrared lamp (Toshiba, 100 V, 375 WR) for 2 hours
2. temperatureat reflux
3. filtrationAn insoluble substance was filtered off
4. concentrationthe filtrate was concentrated
5. custompurified by column chromatography on silica gel