Ethylamine → HCID 20142134, compound

HRID 649245Notes

Reaction equation

HRID 649245 reaction equation
[CH2:1]([C:8](=[CH2:16])[C:9]([NH:11][CH2:12][C:13]([OH:15])=[O:14])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:17]([NH2:19])[CH3:18]>N1C=CC=CC=1>[CH2:1]([O:14][C:13](=[O:15])[CH2:12][NH:11][C:9](=[O:10])[CH:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:16][NH:19][CH2:17][CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 13242777FSCZNKNUJVBMPY-UHFFFAOYSA-N

Product 1

HCID 20142134HCID 20142134, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent2×

Conditions

Temperature
120 °C

Procedure

4 g (13 mmoles) of N-(2-benzyl propenoyl)-glycine p.fluorobenzyl ester, 14, are dissolved in 15 ml of pyridine. 1.02 g (13 mmoles) of ethylamine in solution in the pyridine are added. The solution is heated to 120° C. for 2 hours. At the end of the reaction, the solution is concentrated to 5 ml, and 50 ml of ether are added. A white product precipitates. It is filtered, washed with water, and then with ether. It is recrystallized in a 50/50 CH3OH/H2O mixture. White crystals are obtained.

Workup

  1. customAt the end of the reaction
  2. concentrationthe solution is concentrated to 5 ml, and 50 ml of ether
  3. additionare added
  4. customA white product precipitates
  5. filtrationIt is filtered
  6. washwashed with water
  7. customIt is recrystallized in a 50/50 CH3OH/H2O mixture
  8. customWhite crystals are obtained

Sources & evidence

ORD record
ord-bdef5f1634964f7aafea6be94efd0d6c
Source dataset
uspto-grants-1988_04
Patent number
US04738803

Reaction notes

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