HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1-(4-Acetylphenyl)-1H-pyrrole-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | p-Aminoacetophenone | HCID 7468 | — |
| Reactant | Maleic Anhydride | HCID 7923 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-(4-Acetylphenyl)-1H-pyrrole-2,5-dione | HCID 70660 | 65% |
Reaction Steps
In dimethylacetamide, 98 g of maleic anhydride was reacted with 135 g of p-aminoacetophenone at 140° C. for 4 hours. After the reaction, methyl alcohol was added to the reaction solution to precipitate a solid. The precipitate was recovered by filtration and dried in vacuo to obtain 139 g (a yield of 65%) of p-maleimidoacetophenone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04739075 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-f5b8a2bddf504c86bbdd03fdfea945c1 |
| Source note | uspto-grants-1988_04 |