Water → HCID 13854009, compound

Participants

Reaction Steps

A mixture of 4.23 g (20 m mol) of o-chloroacetoacetanilide, 2.55 g (20 m mol) of o-chloroaniline and 20 ml of toluene, after adding one drop of hydrochloric acid was refluxed for 2 hours while the resulted water was distilled off from the reaction system together with about 10 ml of toluene. After 9.30 g (80 m mol) of N,N,N',N'-tetramethylethylenediamine was added to the remaining solution, a solution of 9.94 g (70 m mol) of 2,2,6-trimethyl-4H-1,3-dioxin-4-one in 25 ml of toluene was dropwise added over a period of 15 minutes.

Provenance & Evidence