1,4-Dibromobutane → HCID 20143086, compound

HRID 649324Notes

Reaction equation

HRID 649324 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1([S:22][CH3:23])[C:15](=[O:16])[N:14]([CH3:17])[C:13]2[CH:18]=[CH:19][CH:20]=[CH:21][C:12]=2[S:11]1.[Br:24][CH2:25][CH2:26][CH2:27][CH2:28]Br>>[Br:24][CH2:25][CH2:26][CH2:27][CH2:28][O:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1([S:22][CH3:23])[C:15](=[O:16])[N:14]([CH3:17])[C:13]2[CH:18]=[CH:19][CH:20]=[CH:21][C:12]=2[S:11]1

Participants

3

Reactant 2

HCID 80561,4-DibromobutaneHCID 14809494HCID 14809494, compound

Product 1

HCID 20143086HCID 20143086, compoundYield 80%

Procedure

3,4-Dihydro-2-(2-hydroxy-5-methoxyphenyl)-4-methyl-2-methylthio-3-oxo-2H-1,4-benzothiazine (3.5 g, compound No. 8) and 1,4-dibromobutane (3.6 ml) are treated by the similar method as in Example 15 to give 3.9 g (80.0%) of the titled compound.

Sources & evidence

ORD record
ord-9ba8fc922afb4b47a7ae2255f342fef1
Source dataset
uspto-grants-1988_04
Patent number
US04739050

Reaction notes

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