Acetic Anhydride → HCID 20143056, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of 3,4-dihydro-2-(4-hydroxyphenyl)-4-methyl-2-methylamino-3-oxo-2H-1,4-benzothiazine (3.0 g, compound No. 66) in acetic anhydride (14.3 ml), fused sodium acetate (3.3 g) is added. The mixture is stirred for 3.5 hours at 85° C. and then poured into a mixture of ethyl acetate and saturated aqueous sodium bicarbonate solution. The separated crystals are collected by filtration to give 3.3 g (85.7%) of the title compound.

Provenance & Evidence