Pinacolone → methyl 5,5-dimethyl-2,4-dioxohexanoate

HRID 649342Notes

Reaction equation

[CH3:1][C:2]([C:4]([CH3:7])([CH3:6])[CH3:5])=[O:3].[CH3:8][O:9][C:10](=[O:15])[C:11](OC)=[O:12]>>[CH3:8][O:9][C:10](=[O:15])[C:11]([CH2:1][C:2](=[O:3])[C:4]([CH3:7])([CH3:6])[CH3:5])=[O:12]

Participants

Reactant 2

HCID 6416Pinacolone

HCID 11120Dimethyl oxalate

Product 1

HCID 4016750methyl 5,5-dimethyl-2,4-dioxohexanoate

Procedure

When a mixture, heated to 50° C., of pinacolin and oxalic acid dimethyl ester was added and the procedure was otherwise the same as in Example 6, a amount of 166.7 g of pivaloylpyruvic acid methyl ester (89% of the theoretical yield) were obtained. Purity: 99.3%.

Workup

additionwas added

Sources & evidence

ORD record: ord-c1bc1e890966421ea264ff069b04b647
Source dataset: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04739104

Reaction notes

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