Bromine → 1-Bromo-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

HRID 649359Notes

Reaction equation

HRID 649359 reaction equation
[CH3:1][C:2]([CH3:23])([CH3:22])[C:3](=[O:21])[CH:4](OC1C=CC(C=NOC)=CC=1)[N:5]1[CH:9]=[N:8][CH:7]=[N:6]1.CC(C)(C)C(=O)CN1C=NC=N1.[Br:36]Br>>[Br:36][CH:4]([N:5]1[CH:9]=[N:8][CH:7]=[N:6]1)[C:3](=[O:21])[C:2]([CH3:23])([CH3:22])[CH3:1]

Participants

4

Reactant 3

HCID 24408BromineHCID 1008773,3-Dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanoneHCID 542576103,3-Dimethyl-1-(4-methoxyiminomethyl-phenoxy)-1-(1,2,4-triazol-1-yl)-2-butanone

Product 1

HCID 130216491-Bromo-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one

Procedure

Thus, for example, it is possible to prepare 3,3-dimethyl-1-(4-methoxyiminomethyl-phenoxy)-1-(1,2,4-triazol-1-yl)-2-butanone of the formula ##STR11## by first reacting 3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanone with bromine to give 1-bromo-1-(1,2,4-triazol-1-yl)-3,3-dimethyl-2-butanone, and then reacting the latter with 4-hydroxybenzaldoxime O-methyl ether in the presence of a base. This synthesis can be illustrated by formulae as follows:

Sources & evidence

ORD record
ord-f87b800f726741dca1bbccb3aac9060c
Source dataset
uspto-grants-1988_04
Patent number
US04739118

Reaction notes

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