HCID 13622538, compound → HCID 70416549, compound

HRID 649383Notes

Reaction equation

HRID 649383 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]([NH:20][C@@H:21]1[C:27](=[O:28])[N:26]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:25]2[CH:37]=[CH:38][CH:39]=[CH:40][C:24]=2[S:23][CH2:22]1)[CH2:7][CH2:8][N:9]1[C:13](=[O:14])[C:12]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:11]2[C:10]1=[O:19])=[O:5])[CH3:2].C(OCC)(=O)C.[ClH:47]>>[ClH:47].[CH2:1]([O:3][C:4]([C@@H:6]([NH:20][C@@H:21]1[C:27](=[O:28])[N:26]([CH2:29][C:30]([OH:32])=[O:31])[C:25]2[CH:37]=[CH:38][CH:39]=[CH:40][C:24]=2[S:23][CH2:22]1)[CH2:7][CH2:8][N:9]1[C:10](=[O:19])[C:11]2=[CH:18][CH:17]=[CH:16][CH:15]=[C:12]2[C:13]1=[O:14])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 13622538HCID 13622538, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70416549HCID 70416549, compound

Procedure

In hydrogen chloride-ethyl acetate solution (5N, 5 ml) is dissolved 0.2 g of tert-butyl 3(R)-[1(S)-ethoxycarbonyl-3-phthalimidopropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate, and the solution is allowed to stand at room temperature for 4 hours. Petroleum ether (100 ml) is added to the reaction solution, and the deposited precipitate is collected by filtration to give 0.18 g of 3(R)-[1(S)-ethoxycarbonyl-3-phthalimidopropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid.hydrochloride as a colorless powder.

Workup

  1. filtrationthe deposited precipitate is collected by filtration

Sources & evidence

ORD record
ord-5e91f9220db044daaf7f7d5da6c73595
Source dataset
uspto-grants-1988_04
Patent number
US04739066

Reaction notes

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