HCID 13622541, compound → HCID 70416307, compound

HRID 649416Notes

Reaction equation

HRID 649416 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]([NH:23][C@@H:24]1[C:30](=[O:31])[N:29]([CH2:32][C:33]([O:35]C(C)(C)C)=[O:34])[C:28]2[CH:40]=[CH:41][CH:42]=[CH:43][C:27]=2[S:26][CH2:25]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16](=[O:17])[C:15]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]2[C:13]1=[O:22])=[O:5])[CH3:2].C(OCC)(=O)C.[ClH:50]>>[ClH:50].[CH2:1]([O:3][C:4]([C@@H:6]([NH:23][C@@H:24]1[C:30](=[O:31])[N:29]([CH2:32][C:33]([OH:35])=[O:34])[C:28]2[CH:40]=[CH:41][CH:42]=[CH:43][C:27]=2[S:26][CH2:25]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:13](=[O:22])[C:14]2=[CH:21][CH:20]=[CH:19][CH:18]=[C:15]2[C:16]1=[O:17])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 13622541HCID 13622541, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70416307HCID 70416307, compound

Procedure

In 5 ml of 5N hydrogen chloride-ethyl acetate solution is dissolved 0.12 g of tert-butyl 3(R)-[1(S)-ethoxycarbonyl-6-phthalimidohexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate, and the solution is left standing at room temperature for 1 hour. Petroleum ether (50 ml) is added to the solution and the deposited precipitate is dried under reduced pressure to give 0.1 g of 3(R)-[1(S)-ethoxycarbonyl-6-phthalimidohexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride as a colorless powder.

Workup

  1. waitthe solution is left
  2. customthe deposited precipitate is dried under reduced pressure

Sources & evidence

ORD record
ord-09baa178c42b40d7896b34f7f32b1d12
Source dataset
uspto-grants-1988_04
Patent number
US04739066

Reaction notes

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