HCID 13622547, compound → HCID 70416284, compound

HRID 649419Notes

Reaction equation

HRID 649419 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]([NH:25][C@@H:26]1[C:32](=[O:33])[N:31]([CH2:34][C:35]([O:37]C(C)(C)C)=[O:36])[C:30]2[CH:42]=[CH:43][CH:44]=[CH:45][C:29]=2[S:28][CH2:27]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:18](=[O:19])[C:17]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:16]2[C:15]1=[O:24])=[O:5])[CH3:2].C(OCC)(=O)C.[ClH:52]>>[ClH:52].[CH2:1]([O:3][C:4]([C@@H:6]([NH:25][C@@H:26]1[C:32](=[O:33])[N:31]([CH2:34][C:35]([OH:37])=[O:36])[C:30]2[CH:42]=[CH:43][CH:44]=[CH:45][C:29]=2[S:28][CH2:27]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:18](=[O:19])[C:17]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:16]2[C:15]1=[O:24])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 13622547HCID 13622547, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70416284HCID 70416284, compound

Procedure

In 5 ml of 5N hydrogen chloride-ethyl acetate solution is dissolved 0.12 g of tert-butyl 3(R)-[1(S)-ethoxycarbonyl-8-phthalimidooctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate, and the solution is left standing at room temperature for 3 hours. Petroleum ether (70 ml) is added to the solution and the deposited precipitate is dried under reduced pressure to give 0.10 g of 3(R)-[1(S)-ethoxycarbonyl-8-phthalimidooctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride as a colorless powder.

Workup

  1. waitthe solution is left
  2. customthe deposited precipitate is dried under reduced pressure

Sources & evidence

ORD record
ord-973a9f3589a24c118b048d4f8936fbdf
Source dataset
uspto-grants-1988_04
Patent number
US04739066

Reaction notes

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