Hydrogen chloride-ethyl acetate → HCID 70416924, compound

HRID 649420Notes

Reaction equation

HRID 649420 reaction equation
[CH2:1]([O:3][C:4]([C@@H:6]([NH:26][C@@H:27]1[C:33](=[O:34])[N:32]([CH2:35][C:36]([O-:38])=[O:37])[C:31]2[CH:39]=[CH:40][CH:41]=[CH:42][C:30]=2[S:29][CH2:28]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[C:19](=[O:20])[C:18]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:17]2[C:16]1=[O:25])=[O:5])[CH3:2].C(OCC)(=O)C.[ClH:49]>>[ClH:49].[CH2:1]([O:3][C:4]([C@@H:6]([NH:26][C@@H:27]1[C:33](=[O:34])[N:32]([CH2:35][C:36]([OH:38])=[O:37])[C:31]2[CH:39]=[CH:40][CH:41]=[CH:42][C:30]=2[S:29][CH2:28]1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][N:15]1[C:19](=[O:20])[C:18]2=[CH:21][CH:22]=[CH:23][CH:24]=[C:17]2[C:16]1=[O:25])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86741237HCID 86741237, compound

Product 1

HCID 70416924HCID 70416924, compound

Procedure

In 5 ml of 5N hydrogen chloride-ethyl acetate solution is dissolved 0.1 g of 3(R)-[1(S)-ethoxycarbonyl-9-phthalimidononyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate, and the solution is left standing at room temperature for 3 hours. Petroleum ether (50 ml) is added to the solution and the deposited precipitate is dried under reduced pressure to give 0.076 g of 3(R)-[1(S)-ethoxycarbonyl-9-phthalimidononyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride as a colorless powder.

Workup

  1. waitthe solution is left
  2. customthe deposited precipitate is dried under reduced pressure

Sources & evidence

ORD record
ord-478e6ad1fd0a4c248e09e1d0dcbf8bdb
Source dataset
uspto-grants-1988_04
Patent number
US04739066

Reaction notes

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