Diethyl Ether → HCID 13622595, compound

HRID 649422Notes

Reaction equation

C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]([NH:22][C@@H:23]1[C:29](=[O:30])[N:28]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])[C:27]2[CH:39]=[CH:40][CH:41]=[CH:42][C:26]=2[S:25][CH2:24]1)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=O)(C)(C)C.CCOCC.C(OCC)(=O)C.[ClH:54]>>[ClH:54].[ClH:54].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]([NH:22][C@@H:23]1[C:29](=[O:30])[N:28]([CH2:31][C:32]([OH:34])=[O:33])[C:27]2[CH:39]=[CH:40][CH:41]=[CH:42][C:26]=2[S:25][CH2:24]1)[C:17]([O:19][CH2:20][CH3:21])=[O:18]

Participants

Reactant 3

HCID 3283Diethyl Ether

HCID 13622577HCID 13622577, compound

HCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 13622595HCID 13622595, compound

Procedure

In 10 ml of 5N hydrogen chloride-ethyl acetate solution is dissolved 0.72 g of tert-butyl 3(R)-[8-tert-butoxycarbonylamino-1(S)-ethoxycarbonyloctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate, and the solution is left standing at room temperature for 3.5 hours. Ether (10 ml) is added to the solution and the deposited precipitate is dried under reduced pressure to give 0.50 g of 3(R)-[8-amino-1(S)-ethoxycarbonyloctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid dihydrochloride as a colorless powder.

Workup

waitthe solution is left
customthe deposited precipitate is dried under reduced pressure

Sources & evidence

ORD record: ord-7f1aa52539c54cf091753e2e4547cdee
Source dataset: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04739066

Reaction notes

Loading…