HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Ciobutide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | ethyl 2-cyano-2-phenylbutanoate | HCID 250114 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ciobutide | HCID 257232 | 80% |
Reaction Steps
A 10% solution of ethyl 2-cyano-2-ethyl-2-phenylacetate in ethanol is saturated with ammonia under cooling. The reaction mixture is allowed to stand at 5° C. for 96 hours, thereafter the solvent and the excess of ammonia are removed, and the product is filtered off. 2-Cyano-2-ethyl-2-phenylacetic acid amide is obtained with a yield of 80%; m.p.: 116.5°-117° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04740228 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-f901cee003404032a021404e55f78111 |
| Source note | uspto-grants-1988_04 |