Morpholine → HCID 14076582, compound

Participants

Reaction Steps

8.7 g (0.1 mole) of morpholine are dissolved in 20 ml of dry diethyl ether, and a solution of 10.5 g (0.05 mole) of 2-ethyl-2-phenyl-cyanoacetyl chloride in 20 ml of dry diethyl ether are added dropwise under cooling with ice (at a temperature below 10° C.). The reaction mixture is refluxed for 30 minutes, then cooled and washed with water. The organic phase is separated, washed in succession with 5% aqueous sodium carbonate solution, 2n aqueous hydrochloric acid and water, dried over magnesium sulfate, and evaporated. 11.4 g (89%) of 2-cyano-2-ethyl-2-phenylacetic acid morpholide are obtained; m.p.: 88°-90° C.

Provenance & Evidence