反应详情

5.0 g (0.012 mole) of 1-(2-chloro-4-trifluoromethoxyphenyl)-4-cyano-5-(N-propionyl-N-n-propylamino)pyrazole in 200 ml of methanol are stirred with 11.6 ml (0.012 mole) of 1 normal sodium hydroxide solution at room temperature for 48 hours. For working up, the mixture is concentrated in vacuo, the residue is taken up in methylene chloride, the mixture is washed twice with 100 ml of water each time, dried iover sodium sulphate and concentrated and the residue is crystallized from petroleum ether. 3.8 g (92% of theory) of 1-(2-chloro-4-trifluoromethoxyphenyl)-4-cyano-5-n-propylamino-pyrazole of melting point 63° C. are obtained.

1. concentrationthe mixture is concentrated in vacuo
2. washthe mixture is washed twice with 100 ml of water each time
3. dry with materialdried iover sodium sulphate
4. concentrationconcentrated
5. customthe residue is crystallized from petroleum ether