Hydroxylamine, O-ethyl- → HCID 178449930, compound

HRID 649440Notes

Reaction equation

HRID 649440 reaction equation
[C:1]([CH:6]1[C:11](=[O:12])[CH2:10][CH:9]([CH:13]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:8][C:7]1=[O:21])(=O)[CH2:2][CH2:3][CH3:4].[CH2:22]([O:24][NH2:25])[CH3:23]>C(O)C>[CH2:22]([O:24][NH:25][C:1](=[C:6]1[C:11](=[O:12])[CH2:10][CH:9]([CH:13]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:8][C:7]1=[O:21])[CH2:2][CH2:3][CH3:4])[CH3:23]

Participants

4

Reactant 2

HCID 69357Hydroxylamine, O-ethyl-HCID 132182702-Butanoyl-5-cyclooctylcyclohexane-1,3-dione

Product 1

HCID 178449930HCID 178449930, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.9 parts by weight of 2-butyryl-5-cyclooctylcyclohexane-1,3-dione, 1.1 parts by weight of ethoxyamine and 80 parts by volume of ethanol were stirred at room temperature for 12 hours, the solvent was distilled off under reduced pressure, the residue was taken up in 150 parts of dichloromethane, the solution was washed twice with water and dried over sodium sulfate, and the solvent was distilled off under reduced pressure. 2-(1-ethoxyamino-butylidene)-5-cyclooctylcyclohexane-1,3-dione was obtained in 94% yield as an oil (compound no. 1); nD33 : 1.5234.

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. washthe solution was washed twice with water
  3. dry with materialdried over sodium sulfate
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-67375216e25240cdb0cf4440fec49dd1
Source dataset
uspto-grants-1988_04
Patent number
US04740237

Reaction notes

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