4,5-Dihydro-2-(methylthio)thiazole → 3-[2-(2,5-Diketopyrrolidyl)ethyl]-2-methylthiothiazolinium bromide

Participants

Reaction Conditions

Reaction Steps

6.6 g (5×10-2 mols) of 2-methylthiothiazoline and 12.0 g (6×10-2 mols) of 2-(2,5-diketopyrrolidyl)ethyl bromide were heated with stirring for about 3 hours on an oil bath which had been heated to a temperature of 130° C. Thereafter, the reaction system was allowed to cool to room temperature. 50 ml of acetone was added to the reaction system. The resulting precipitate was recovered by decantation. 11.1 g of the desired product was obtained in a 66% yield.

Provenance & Evidence