Chlorosulfonic acid → HCID 131715505, compound

HRID 649500Notes

Reaction equation

HRID 649500 reaction equation
[CH3:1][O:2][CH:3]1[CH:7]2[CH2:8][CH2:9][CH:4]1[C:5]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][C:6]=12.[Cl:16][S:17](O)(=[O:19])=[O:18]>C(Cl)(Cl)Cl>[Cl:16][S:17]([C:13]1[C:5]2[CH:4]3[CH:3]([O:2][CH3:1])[CH:7]([CH2:8][CH2:9]3)[C:6]=2[CH:10]=[C:11]([O:14][CH3:15])[CH:12]=1)(=[O:19])=[O:18]

Participants

4

Reactant 2

HCID 24638Chlorosulfonic acidHCID 131715506HCID 131715506, compound

Product 1

HCID 131715505HCID 131715505, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A small amount of chloroform was added to 50 g of 3,6-dimethoxybenzonorbornene, and the mixture was stirred with cooling by ice water. Chlorosulfonic acid (65 ml) was slowly added to this. After the mixture was reacted at 0° C. for 1 hour, the reaction solution was poured over ice. It was extracted with diethyl ether. The extract solution was dried over anhydrous sodium sulfate and then the diethyl ether was distilled off, giving 4-chlorosulfonyl-3,6-dimethoxybenzonorbornene. Yield: 58%.

Workup

  1. customAfter the mixture was reacted at 0° C. for 1 hour
  2. additionthe reaction solution was poured over ice
  3. extractionIt was extracted with diethyl ether
  4. dry with materialThe extract solution was dried over anhydrous sodium sulfate
  5. distillationthe diethyl ether was distilled off

Sources & evidence

ORD record
ord-8c3654eee715456dafbc5d710b21ca05
Source dataset
uspto-grants-1988_04
Patent number
US04740453

Reaction notes

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