Azane;hydrate → HCID 14009793, compound

HRID 649504Notes

Reaction equation

HRID 649504 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([OH:15])[CH:10]=2)=[CH:6][CH:7]=1.O.N>C(O)C.[Pd]>[OH:15][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=1)[O:8][C:5]1[N:4]=[N:3][CH:2]=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 12896473Azane;hydrateHCID 14009794HCID 14009794, compound

Product 1

HCID 14009793HCID 14009793, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

11.1 g of 3-chloro-6-(3-hydroxyphenoxy)pyridazine are dissolved in 100 ml of ethanol, followed by addition of 6 ml of concentrated ammonia water and 1.0 of 5% Pd-C. Then catalytic reduction is carried out at 50° C. under atmospheric pressure. The theroretical amount of hydrogen gas is almost completely absorbed in about 1 hour. The reaction mixture is filtered and the filtrate is concentrated to dryness.

Workup

  1. customis carried out at 50° C. under atmospheric pressure
  2. customThe theroretical amount of hydrogen gas is almost completely absorbed in about 1 hour
  3. filtrationThe reaction mixture is filtered
  4. concentrationthe filtrate is concentrated to dryness

Sources & evidence

ORD record
ord-bb7914be8ba14ccdad7de84602157ae7
Source dataset
uspto-grants-1988_04
Patent number
US04740505

Reaction notes

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