HCID 3035543, compound → HCID 6509858, compound

HRID 649527Notes

Reaction equation

HRID 649527 reaction equation
[CH3:1][O:2][C:3]1[C:9]2[S:10][CH:11]=[CH:12][C:8]=2[C:7](=[CH:13][C:14]([OH:16])=[O:15])[C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[CH:4]=1>C(O)C>[CH3:1][O:2][C:3]1[C:9]2[S:10][CH:11]=[CH:12][C:8]=2/[C:7](=[CH:13]\[C:14]([OH:16])=[O:15])/[C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[CH:4]=1

Participants

3

Reactant 1

HCID 3035543HCID 3035543, compound

Product 1

HCID 6509858HCID 6509858, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The isomer mixture product of example 2 is dissolved in 1 l boiling 95% ethanol, seeded with crystals of the pure (Z) isomer obtained in accordance with example (5a1) above and allowed to cool slowly with stirring. After standing for 20 hours the yellow crystal mass is filtered off and pressed. The pure (Z)-[10-methoxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene]-acetic acid is obtained following re-crystallisation from ethanol: m.p.=184°-187° C.

Workup

  1. customobtained in accordance with example (5a1) above and
  2. temperatureto cool slowly
  3. filtrationthe yellow crystal mass is filtered off

Sources & evidence

ORD record
ord-3e01082515284821b0428fc872ccdd72
Source dataset
uspto-grants-1988_04
Patent number
US04740518

Reaction notes

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