Bromine → HCID 20141813, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-fluorochromanone 99.6 g, 0.6 mol) in 500 ml of acetic acid, 96.0 g (0.6 mol) of bromine were added in dropwise at a rate so as to maintain a reaction temperature at 25° C. After stirring the reactants for 2.0 hours at 25° C., the reaction mixture was poured into 1.2 liter of cracked ice with stirring. Resulting precipitate was subsequently filtered, washed with water and then dried on air to give 140 g (95.2%) of the desired compound.

Provenance & Evidence