Thionyl Chloride → HCID 13936003, compound

Participants

Reaction Conditions

Reaction Steps

A mixture consisting of 6-fluoro-4-hydroxy-3,4-dihydro-2H-1-benzopyran-4-carboxamide (60 mg, 0.28 mmol) and thionylchloride (60 mg, 0.28 mmol) in 1.0 ml of diethyl ether was stirred for 5.0 hours at 28° C. The reaction mixture was evaporated in vacuo to give a pale yellowish oil which was chromatographed on silica gel, eluting with ethyl ether to give 43 mg (67.2%) of the desired refined compound.

Provenance & Evidence