HCID 14350348, compound → HCID 70418029, compound

HRID 649536Notes

Reaction equation

HRID 649536 reaction equation
I[C:2]1[N:3]=[C:4]([CH3:19])[N:5]([C:7]2[CH:8]=[C:9]3[C:14](=[C:15]([CH3:17])[CH:16]=2)[NH:13][C:12](=[O:18])[CH:11]=[CH:10]3)[CH:6]=1.[Cl-].[F:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[Zn+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[F:21][C:22]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:23]=1[C:2]1[N:3]=[C:4]([CH3:19])[N:5]([C:7]2[CH:8]=[C:9]3[C:14](=[C:15]([CH3:17])[CH:16]=2)[NH:13][C:12](=[O:18])[CH:11]=[CH:10]3)[CH:6]=1

Participants

4

Reactant 2

HCID 14350348HCID 14350348, compoundHCID 178505909HCID 178505909, compound

Product 1

HCID 70418029HCID 70418029, compound

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

This compound, m.p. 262°-5°, was prepared similarly to Example 11 using 6-(4-iodo-2-methylimidazol-1-yl)-8-methyl-2-(1H)-quinolone, 2,4-difluorophenyl zinc chloride and tetrakis(triphenylphosphine)palladium (O) as the starting materials:

Sources & evidence

ORD record
ord-b8a5181a974043ed9fb78665e12b345e
Source dataset
uspto-grants-1988_04
Patent number
US04740513

Reaction notes

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