Ammonia → HCID 19867092, compound

Participants

Reaction Steps

A mixture of 6-(4-Iodo-2-methylimidazol-1-yl)-8-methyl-2-(1H)-quinolone (0.55 g), cuprous cyanide (0.27 g) and palladium acetate (0.03 g) in 1-methyl-2-pyrrolidone (5 cm3) was heated and stirred at 175° for 2 hours. The cooled mixture was poured into aqueous ammonia solution (30 cm3 ; S.G. 0.880) and extracted with dichloromethane (3×100 cm3). The combined and dried (MgSO4) organic extracts were filtered and evaporated in vacuo and the residue was chromatographed on silica (Merck "MK 60.9385" [Trade Mark]) eluting with chloroform. Combination and evaporation of the appropriate fractions afforded the title compound, m.p. >350°, (0.22 g).

Provenance & Evidence