HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 13934585, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Hydroxy-3-(2-hydroxypropyl)-1-phenyl-1,8-naphthyridin-2(1H)-one | HCID 54717821 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 13934585 | HCID 13934585 | — |
Reaction Steps
A suspension of 4-hydroxy-3-(2-hydroxypropyl)1-phenyl-1,8-naphthyridin-2(lH)-one (1 g.) in CH2CL2 was stirred in an atmosphere of nitrogen. To this was added pyridine (1.5 ml.). To this mixture was added a solution of SOCl2 (1.5 ml.) in CH2Cl2 (10 ml.) dropwise over a period of 15 minutes. The mixture was stirred overnight at room temperature then water was added. The CH2Cl2 layer was separated, dried and evaporated. Recrystallization from isopropanol yielded the product, m.p. 207°-209° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04740511 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-28243fe2376a4098aabafb3b6d1f6039 |
| Source note | uspto-grants-1988_04 |