Acetic Anhydride → HCID 178473767, compound

HRID 649571Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:20](=[O:21])[C:11]3=[CH:12][NH:13][C:14]4[CH2:15][CH2:16][NH:17][CH2:18][C:19]=4[C:10]3=[N:9]2)=[CH:4][CH:3]=1.[C:22](OC(=O)C)(=[O:24])[CH3:23]>>[C:22]([N:17]1[CH2:16][CH2:15][C:14]2[NH:13][CH:12]=[C:11]3[C:20](=[O:21])[N:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)[N:9]=[C:10]3[C:19]=2[CH2:18]1)(=[O:24])[CH3:23]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 178515180HCID 178515180, compound

Product 1

HCID 178473767HCID 178473767, compound

Procedure

2-p-Chlorophenyl-2,3,6,7,8,9-hexahydropyrazolo[4,3-c][1,6]naphthyridin-3(5H)-one is treated with an excess of acetic anhydride with heating to obtain 8-acetyl-2-p-chlorophenyl-2,3,6,7,8,9-hexahydropyrazolo[4,3-c][1,6]naphthyridin-3(5H)-one, mp above 350°; IR: 1640,1670 cm-1.

Workup

temperaturewith heating

Sources & evidence

ORD record: ord-cd00f7718ed142f8bf16e57bc32c2453
Source dataset: uspto-grants-1988_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04740512

Reaction notes

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