Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Methoxybenzoic Acid | HCID 7478 | — |
| Reactant | 4-Methylanisole | HCID 7731 | — |
| Reactant | Sodium Bromide | HCID 253881 | — |
| Catalyst | Titanium | HCID 23963 | — |
| Product | 4-Methoxybenzaldehyde | HCID 31244 | — |
Reaction Conditions
| Temperature | 250 fahrenheit |
|---|
Reaction Steps
Two hundred and thirty (230) g. (1.89 moles) p-methylanisole, 399 g. (6.65 moles) acetic acid, 21 g. (1.17 moles) water, 1.73 g. (0.007 moles) Co(OAc)2 0, 1.7 g. (0.007 moles) Mn(OAc)2.4H2 0 and 1.4 g. (0.014 moles) NaBr were combined in a two-liter titanium-clad autoclave. The reactor was heated to 250° F. and pressurized to 150 psi. The air rate was ramped up to reach a value of 0.78 scf/min after 15 minutes. During the oxidation the temperature and pressure were gradually increased to reach final values of 324° F. and 250 psi. The oxidation was complete after 30 minutes. Analysis of the reaction mixture showed p-anisic acid, 85 mole % yield, and p-anisaldehyde, 1.2 mole % yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04740614 |
|---|
| Source dataset | uspto-grants-1988_04 |
|---|
| ORD ID | ord-6517ce408c164a618be0f3ed6d900681 |
|---|
| Source note | uspto-grants-1988_04 |
|---|
