Methanol → Permethric acid

Participants

Reaction Steps

In similar way to that in Stage IV-1 Example 3 above except that 5 g of methyl 2,2-dimethyl-3-(2',2',2'-trichloroethyl)-cyclopropanecarboxylate (purity: 95.8%, cis/trans: 92.7/7.3) were added to a mixture of 4 g of sodium hydroxide, 20 ml of methanol and 30 ml of water to heat the resulting mixture for 10 hours under reflux, 3.31 of 2,2-dimethyl-3-(2',2'-dichlorovinyl)-cyclopropanecarboxylic acid, cis/trans ratio 98.8/1.2, purity 96.4%, yield 81.7% were obtained.

Provenance & Evidence