HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydro[1]benzothieno[2,3-c]pyridine → 2-[4-(3-Indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydro[1]benzothieno[2,3-c]pyridine | HCID 413282 | — |
| Reactant | 3-(4-Chlorobutyl)indole | HCID 13327011 | — |
| Reactant | 3-(4-Bromobutyl)-1h-indole | HCID 14201179 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-[4-(3-Indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine | HCID 13747486 | — |
Reaction Steps
A solution of 20.8 g of 3-(4-chlorobutyl)indole [or 25.2 g of 3-(4-bromobutyl)indole] and 18.9 g of 1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine in 100 ml of acetonitrile is stirred at 20° for 12 hours. The usual working up is carried out, and 2-[4-(3-indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine ("A"), m.p. 113°-115° is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04740602 |
| Source dataset | uspto-grants-1988_04 |
| ORD ID | ord-f801927f389c460fae4d178df9f4bbd8 |
| Source note | uspto-grants-1988_04 |