Water → HCID 21243289, compound

Participants

Reaction Steps

A suspension of 40.2 g of 2-[4-(5-methoxy-3-indolyl)-1,4-dioxobutyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine [obtainable from 4-(5-methoxy-3-indolyl)-4-oxobutyric acid and 1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine] in 3 l of hot absolute THF is added dropwise, with stirring, to a suspension of 23.4 g of LiAlH4 in 1100 ml of absolute THF, and the mixture is boiled for 1 hour, cooled, and decomposition is carried out with water and sodium hydroxide solution, and the usual working up is carried out. 2-[4-(5-methoxy-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine is obtained, Rf 0.5 (ethyl acetate).

Provenance & Evidence