Sodium Hydroxide → 2-[4-(5-Hydroxymethyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine

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Reaction Steps

A solution of 3.88 g of 2-[4-(5-carboxy-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine in 40 ml of THF is added dropwise to a stirred suspension of 0.76 g of lithium aluminium hydride in 30 ml of THF under N2. The mixture is then stirred at 20° for 2 hours, decomposition is carried out with dilute sodium hydroxide solution and then with water, and the mixture is filtered. The usual working up is carried out on the filtrate. 2-[4-(5-Hydroxymethyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine is obtained.

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