Sodium Hydroxide → HCID 21243266, compound

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Reaction Steps

A solution of 4.18 g of 2-[4-(5-methoxycarbonyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine in 40 ml of THF is added dropwise to a stirred suspension of 0.57 g of lithium aluminium hydride in 20 ml of THF at 20° under N2. The mixture is stirred at 20° for 1 hour, and decomposition is carried out with dilute sodium hydroxide solution and then with water, and the mixture is filtered, the usual working up is carried out on the filtrate, and 2-[4-(5-hydroxymethyl-3-indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine is obtained.

Provenance & Evidence