HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131722824, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- | HCID 85083 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 131722825 | HCID 131722825 | — |
| Reactant | HCID 131722826 | HCID 131722826 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131722824 | HCID 131722824 | 73% |
Reaction Steps
After cleavage of the Boc group from Boc-Ile-Phe-Oallyl according to general procedure D, the HCl salt of Ile-Phe-Oallyl was coupled to Boc-Pro in DMF (60 ml) via general procedure C, by using TEA (1.94 ml, 13.9 mmol), HOBt (3.047 g, 19.9 mmol), and EDCl (2.79 g. 14.6 mmol). After workup, the product was crystallized from cold EthOAc to give the title compound in 73% yield as a white solid. Rf=0.30 (50% EthOAc/hexane). [α]D23=−60.5 (c 0.585, CHC3). FABMS (C28H41N3O6) found 516.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06270957B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-15e7c2cd25b949f9a9406f8723230515 |
| Source note | uspto-grants-2001_08 |