HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(Chloromethyl)-3-methylpyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-methyluracil-5-carboxylic acid | HCID 253771 | — |
| Product | 5-(Chloromethyl)-3-methylpyrimidine-2,4(1H,3H)-dione | HCID 21821995 | 52% |
Reaction Steps
3-methyluracil-5-carboxylic acid was treated with HCl and CH2 using standard chloromethylation conditions to give 3-methyl-5-chloromethyl uracil in 52% yield (following standard work-up and recrystallization from ethyl acetate). NMR (DMSO-d6): chemical shifts, peak integrations L D2O exchange experiments diagnostic for structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271195B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-f8d97e719f024197adad569f1992e044 |
| Source note | uspto-grants-2001_08 |