UK-343664 → HCID 135487819, compound

HRID 649769Notes

Reaction equation

HRID 649769 reaction equation
N1NC=C2C=1[C:8](=[O:10])NC=N2.[CH2:11]([O:13][C:14]1[C:19]([C:20]2[NH:21][C:22](=[O:35])[C:23]3[N:28](CCOC)[N:27]=[C:26]([CH2:33][CH3:34])[C:24]=3[N:25]=2)=[CH:18][C:17]([S:36]([N:39]2[CH2:44][CH2:43][N:42]([CH2:45][CH3:46])[CH2:41][CH2:40]2)(=[O:38])=[O:37])=[CH:16][N:15]=1)[CH3:12].C(C1N([CH2:80][C:81]2[CH:86]=[CH:85][CH:84]=[CH:83][N:82]=2)N=C2C(=O)NC(C3C=C(S(N4CCN(CC)CC4)(=O)=O)C=CC=3OCCC)=NC=12)C>>[CH2:11]([O:13][C:14]1[C:19]([C:20]2[NH:21][C:22](=[O:35])[C:23]3[C:24](=[C:26]([CH2:33][CH3:34])[N:27]([CH2:80][C:81]4[CH:86]=[CH:85][CH:84]=[C:83]([O:10][CH3:8])[N:82]=4)[N:28]=3)[N:25]=2)=[CH:18][C:17]([S:36]([N:39]2[CH2:44][CH2:43][N:42]([CH2:45][CH3:46])[CH2:41][CH2:40]2)(=[O:38])=[O:37])=[CH:16][N:15]=1)[CH3:12]

Participants

4

Reactant 3

HCID 135430996UK-343664HCID 135721190HCID 135721190, compoundHCID 178518714HCID 178518714, compound

Product 1

HCID 135487819HCID 135487819, compound

Procedure

5-[2-i-butoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridin-3-yl]-2,3-diethyl-2,6-dihydro-7H-pyrazolo[[4,3-d]pyrimidin-7-one; 5-[2-ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridin-3-yl]-3-ethyl-2-[1-pyridin-2-yl)ethyl]2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-[2-Ethoxy-5-(4-ethylpiperazin-1-ylsulphonyl)pyridin-3-yl]-3-ethyl-1-(2-methoxyethyl)-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; 3-Ethyl-5-[5-(4-ethylpiperazin-1-ylsulphonyl)-2-propoxyphenyl]-2-(pyridin-2-yl)methyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; 5-(2-ethoxy-5-(2-(4-morpholino)acetyl)phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one or the pharmaceutically acceptable salts thereof.

Sources & evidence

ORD record
ord-7f4211a07ad548f8b6d684e91c793280
Source dataset
uspto-grants-2001_08
Patent number
US06271228B1

Reaction notes

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