Hydroquinone → N-Formylmethyl-N-(2-pyridyl)cyclohexanecarboxamide

Participants

Reaction Conditions

Reaction Steps

A solution consisting of 0.6 g of Compound 1A, 0.02 g of hydroquinone in 10 mL of 2 N HCl was stirred, under a nitrogen atmosphere, for 0.5 h at a temperature of 80° C. The resultant mixture was then cooled with a water bath and ice, followed by alkalinization with a 5% aqueous sodium carbonate solution (pH=9), and then by extraction with dichloromethane (2×10 mL). The obtained organic phase was dried over anhydrous sodium sulphate and evaporated to dryness. The obtained end-product material (Compound 1B; yield 68%) was suitable for use in subsequent reactions, with no additional purification processing.

Provenance & Evidence