Tetrahydrofuran → HCID 21713926, compound

Participants

Reaction Steps

A mixture consisting of 1.70 g of compound of Example 5, 18 mL of tetrahydrofurane, 18 mL of methanol, 50 mg of Nichel-Raney and 1 mL of hydrazine hydrate was stirred for 2 h, at room temperature, followed by the addition of 1 mL of hydrazine hydrate, and stirred for 1 h, at a temperature of 50° C. The catalyst was then filtered out, and the recovered solution was evaporated to dryness, affording the crude product, which was then purified by flash chromatography (ethyl acetate—3 N solution of ammonia, in methanol; 95:5). Subsequent evaporation of the solvents afforded 1.33 g of the title compound (yield 84%).

Provenance & Evidence