Chloroform → HCID 21713912, compound

Participants

Reaction Steps

A mixture consisting of 0.35 g of compound of Example 6, 5 mL of chloroform and 0.063 mL of acetyl chloride was stirred for 2.5 h at room temperature, followed by dilution with 50 mL of dichloromethane. The obtained organic phase was then washed with a saturated sodium carbonate solution, and twice with water, followed by drying over anhydrous sodium sulphate and evaporation of the solvents to dryness. The obtained crude product was then purified by flash chromatography (ethyl acetate—3 N solution of ammonia, in methanol; 95:5), and the recovered fraction was evaporated to dryness, affording 0.300 g of the title compound (yield 78%).

Provenance & Evidence