HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 2-chloro-N-(2-chloro-4-nitrophenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 2-Chloro-4-nitroaniline | HCID 8492 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-chloro-N-(2-chloro-4-nitrophenyl)acetamide | HCID 3733641 | — |
Reaction Steps
A solution of 2-chloro-4-nitroaniline (19.0 g) and chloroacetyl chloride (30 mL) in tetrahydrofuran (150 mL) is heated at reflux for 1 hour. The solution is cooled and concentrated under reduced pressure, giving a wet yellow solid. Ether (250 mL) is added and the yellow solid is collected.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06271236B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-17525c6e271649c59264ea0a00d463e4 |
| Source note | uspto-grants-2001_08 |