Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Captamine Hydrochloride | HCID 25798 | — |
| Reactant | 2-chloro-N-(2-chloro-4-nitrophenyl)acetamide | HCID 3733641 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 18543578 | HCID 18543578 | — |
Reaction Steps
To a solution of N-(chloroacetyl)-2-chloro-4-nitroaniline (3.01 g) in N,N-dimethylformamide (100 mL) is added powdered sodium carbonate (6.0 g) and 2-dimethylaminoethanethiol hydrochloride (6.0 g). The mixture is stirred for 1 hour at 25° C., poured into water and extracted into ethyl acetate. The ethyl acetate solution is dried over anhydrous potassium carbonate and concentrated under reduced pressure to give an oil. The oil is crystallized from toluene-hexanes (3:1) to yield a pale yellow crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06271236B1 |
|---|
| Source dataset | uspto-grants-2001_08 |
|---|
| ORD ID | ord-6bb4501e39bf4739ab8c6f0c4cbff0b8 |
|---|
| Source note | uspto-grants-2001_08 |
|---|
