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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 649899Generated: October 26, 2026

1,2,4-Trifluoro-5-nitrobenzene → Ethyl 2-(4,5-difluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate

https://huagongshe.com/reaction/649899

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2,4-Trifluoro-5-nitrobenzeneHCID 75012—
ReactantEthyl 2-amino-1-benzothiophene-3-carboxylateHCID 699464—
SolventDimethyl SulfoxideHCID 679—
ProductEthyl 2-(4,5-difluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylateHCID 18422335—

Reaction Steps

In the same manner as in Starting Material Synthesis Example 4 and using ethyl 2-aminobenzo[b]thiophene-3-carboxylate, 2,4,5-trifluoronitrobenzene and dimethyl sulfoxide, ethyl 2-(4,5-difluoro-2-nitroanilino)benzo[b]thiophene-3-carboxylate is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06271225B1
Source datasetuspto-grants-2001_08
ORD IDord-21b2f5c3ff864378a970711af5396409
Source noteuspto-grants-2001_08